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Updated: Jul 12, 2026

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定位合成克隆和哺乳动物昼夜突变tau的功能特征

P L Lowrey1, K Shimomura, M P Antoch

  • 1Department of Neurobiology and Physiology, Howard Hughes Medical Institute, Northwestern University, Evanston, IL 60208, USA.

Science (New York, N.Y.)
|April 25, 2000
PubMed
概括

叙利亚仓鼠的陶突变通过改变素激酶Iepsilon (CKIε) 来缩短昼夜节律. 这种分子鉴定揭示了CKIε功能障碍如何影响PERIOD蛋白质酸化和日常节律.

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...