在为白血病治疗的儿童中出现遗传不稳定性
B A Finette1, A C Homans, R J Albertini
1Department of Pediatrics, Vermont Cancer Center, University of Vermont, Medical Alumni Building, Burlington, VT 05405, USA. finette@salus.med.uvm.edu
Science (New York, N.Y.)
|April 25, 2000
概括
针对白血病的化疗可能会导致健康T细胞的遗传不稳定,导致突变. 这一发现表明,在一些患者中,发展二次癌症和药物耐药性的潜在机制.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 癌细胞的特点是遗传不稳定.
- 化疗对非恶性细胞的影响尚未完全理解.
- 乙系急性淋巴细胞白血病 (ALL) 是血液和骨髓的癌症.
研究的目的:
- 为了调查是否发生基因不稳定性发生在非恶性T细胞的化学治疗B系ALL后.
- 探索T细胞中化疗诱导的遗传不稳定性的潜在影响.
主要方法:
- 从以前治疗B系ALL的患者中分析T细胞.
- 在素酸转移酶 (HPRT) 记者基因中检测突变.
- 鉴定T细胞受体β (TCRbeta) 基因重组的特征,以确定独立的细胞群.
主要成果:
- 在治疗患者的T细胞的HPRT基因中发现了多种突变.
- 突变的T细胞表现出相同的TCRbeta基因高变区,表明独立的起源.
- 这些发现与非恶性T细胞中的遗传不稳定性表型一致.
结论:
- 癌症治疗,特别是ALL的化疗,可以诱导某些个体的非恶性T细胞的遗传不稳定性.
- 这种不稳定性可能是导致第二恶性瘤发展的机制.
- 化学疗法诱导的T细胞的遗传不稳定性也可能在获得的耐药性中发挥作用.
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