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Murine Model for Parkinson's Disease: from 6-OH Dopamine Lesion to Behavioral Test
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在亨廷顿病的条件模型中,神经病理和运动功能障碍的逆转

A Yamamoto1, J J Lucas, R Hen

  • 1Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA.

Cell
|April 25, 2000
PubMed
概括

亨廷顿病 (HD) 的症状和蛋白质聚合物可能是可逆的. 在有症状的小鼠中阻断突变的亨廷丁蛋白表达减少了包括和改善了运动功能,这表明持续的蛋白质流入是关键.

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