区域性心脏高内核和心室节律失常之间的关系
J M Cao1, M C Fishbein, J B Han
1Division of Cardiology, University of California Los Angeles School of Medicine, 90027, USA.
Circulation
|April 26, 2000
概括
心脏中交感神经密度增加与严重心力衰竭患者的自发性心室节律失常有关. 这表明,受伤后神经的异常再生可能导致心脏突然死亡.
科学领域:
- 心脏病学 心脏病学
- 神经科学是一个神经科学.
- 病理学 病理学 病理学
背景情况:
- 交感神经活动在心室心律失常中起作用.
- 对于心交感神经分布和人类心室节律失常的理解有限.
研究的目的:
- 研究心交感神经分布与人类自发性心室节律失常之间的关系.
主要方法:
- 研究了65个人类心脏 (移植受体,尸检,切除的心室组织).
- 使用免疫细胞化学染色 (S100,神经纤维,铁酸酶,PGP 9.5) 来分析交感神经的分布和密度.
- 相关的神经密度与心室心律不整的记录历史.
主要成果:
- 在患有心室节律失常的心脏中,在患病的心肌和血管周围观察到交感神经的区域性增加.
- 患有心室失常病史的患者 (1A组) 与没有心室失常病史的患者 (1B组) 相比,总神经数量和长度显著增加.
- 左心室喷射分数显著减少 (0.22+/-0.07).
结论:
- 自发性心室失常史与严重心力衰竭中同情神经密度增加之间存在关联.
- 在受伤后异常增加的交感神经密度可能会导致心室节律失常和心脏突然死亡.
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