在Mycobacterium结核病感染中,CD1c介导的T细胞对异oprenoid糖脂的识别
D B Moody1, T Ulrichs, W Mühlecker
1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. bmoody@rics.bwh.harvard.edu
研究人员发现了一种新的脂质抗原类,即由CD1c分子呈现的异oprenoid甘油脂. 这些抗原在Mycobacterium结核病感染期间被T细胞识别,这表明它们在免疫反应中的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 葡萄糖生物学 葡萄糖生物学
背景情况:
- CD1抗原呈现途径包括脂质,但天然的脂质抗原和CD1受限制的T细胞功能尚未完全理解.
- 异oprenoid甘油脂在进化过程中得到保存,对于蛋白质糖化和细胞壁合成至关重要.
研究的目的:
- 为了识别由CD1c受限T细胞识别的新型脂质抗原.
- 为了研究CD1-受限T细胞在对菌根菌感染的反应中的作用.
主要方法:
- 描述T细胞抗原受体和CD1c与脂质抗原的相互作用.
- 分析受感染个体T细胞对菌根细菌糖脂的反应.
主要成果:
- 一个保存的异oprenoid甘油脂家族,包括hexosyl-1-phosphoisoprenoids和mannosyl-beta1-phosphodolichols,被确定为CD1c呈现的抗原.
- 来自M.结核病感染个体的CD1c受限制的T细胞和T淋巴细胞识别了mannosyl-beta1-phosphodolichols.
- 原始人没有反应,这表明在适应性免疫力中发挥了作用.
结论:
- 已经定义了一个新类广泛分布的脂质抗原,在感染期间由CD1系统呈现.
- 这一发现表明一种潜在的免疫机制可以识别老化或转变的细胞与改变的多利霍尔脂质.
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