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Updated: Jun 30, 2026

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在圣路易斯的抗素表型

J A Pierce, B Eradio, T A Dew

    JAMA
    |February 10, 1975
    PubMed
    概括

    圣路易斯捐赠者的抗素表型显示出比斯堪的纳维亚群体更少的蛋白酶抑制剂 (Pi) Z等位基因. 与其他参与者相比,黑人个体中主要的抗素变异较少.

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    Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...