易怒预测冠心病风险:从社区动脉样硬化风险 (ARIC) 研究的前性分析
J E Williams1, C C Paton, I C Siegler
1University of North Carolina, Chapel Hill, NC 27514, USA. janice.williams@sph.unc.edu
Circulation
|May 3, 2000
概括
高特征的愤怒增加了冠心病 (CHD) 风险在normotensive个体. 这项研究发现,容易生气的人在没有高血压的人群中增加了心血管疾病事件的风险和死亡率.
科学领域:
- 心血管健康 心血管健康
- 心理对身体健康的影响
- 心脏病的流行病学心脏病的流行病学.
背景情况:
- 越来越多的证据将愤怒与不良的心血管结果联系在一起.
- 冠心病 (CHD) 仍然是全球死亡的主要原因.
- 了解心血管疾病的心理风险因素对于预防至关重要.
研究的目的:
- 为了前性地研究特征愤怒与心脏病风险之间的关联.
- 检查结合事件和"硬"事件 (急性心肌梗塞/致命性心脏病) 与心脏病风险相关的风险.
- 探索基于高血压状态的愤怒和心脏病相关的潜在异质性.
主要方法:
- 一项前性队列研究,涉及12,986名黑人和白人男性和女性,来自"社区动脉样硬化风险研究".
- 评估特征愤怒程度 (低,中等,高).
- 使用多变量Cox比例危险模型调整生物风险因素并分析事件率.
主要成果:
- 与较低愤怒的人相比,具有高愤怒特征的个人表现出结合性心血管疾病 (HR=1.54) 和"硬"心血管疾病事件 (HR=1.75) 的风险增加.
- 在正常压力个体中观察到剂量反应关系,较高的愤怒水平与显著增加的心脏病风险相关 (例如,高愤怒HR=2.20联合心脏病).
- 在高血压患者中,没有发现特征愤怒和心脏病风险之间的统计学意义上的关联.
结论:
- 易怒是正常压力中年成人心血管疾病发病率和死亡率的重要独立风险因素.
- 这些发现强调了愤怒管理在特定人群心血管疾病预防策略中的重要性.
- 这项研究强调了在心血管疾病评估中需要考虑心理因素与传统的生物风险因素一起.
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