相关实验视频
Updated: Jul 25, 2026

05:41
Purification of Platelets from Mouse Blood
Published on: May 7, 2019
血小板是血小板的组成部分
1Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA. Jim-George@OUHSC.edu
Lancet (London, England)
|May 9, 2000
概括
血小板对于血液凝固和预防出血至关重要. 了解血小板功能和血小板蛋白信号传递是治疗出血障碍和血栓性疾病的关键.
科学领域:
- 血液学 血液学 血液学
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 血小板来自巨核细胞,对于血液静止和血栓状况至关重要.
- 血栓形成素通过与血小板和巨核细胞上的c-mpl受体结合来调节巨核细胞的发展.
- 血小板膜糖蛋白促进对子内皮组织的粘附和聚合,形成静血栓.
研究的目的:
- 阐明血小板在血液静止和血栓性疾病中的作用.
- 了解由血栓形成素调节的巨核细胞发育机制.
- 突出血小板功能调节的治疗潜力.
主要方法:
- 对有关血小板生物学和功能的现有文献的综述.
- 对血栓形成素信号通路的分析.
- 检查血小板膜糖蛋白在粘附和聚合中的作用.
主要成果:
- 血小板在血液静止和血栓形成中起着双重作用.
- 血栓形成素-c-mpl相互作用是巨核细胞发育的核心.
- 血小板功能障碍或血小板数量低导致出血.
- 血小板膜糖蛋白对于凝块形成至关重要.
结论:
- 血小板功能对于维持血管完整性和防止过度出血至关重要.
- 向血栓形成素或血小板功能为心血管和脑血管疾病提供治疗策略.
- 对血小板生物学的进一步研究可能会导致治疗出血和凝血障碍的新方法.
相关概念视频
Fluid Connective Tissues: Blood and Lymph
Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
Blood
The blood flows through blood vessels— arteries, capillaries, and veins. Blood plasma is primarily made of proteins, solutes, and water.
Blood
The blood flows through blood vessels— arteries, capillaries, and veins. Blood plasma is primarily made of proteins, solutes, and water.
Characteristics and Functions of Blood
Blood is specialized connective tissue comprising about 8% of the body mass. It has a thick, liquid extracellular matrix that contains cells, dissolved proteins, and electrolytes, making it five times more viscous than water. Blood is warm, around 38°C, and has an alkaline pH ranging from 7.35 to 7.45.
The primary function of blood is to transport oxygen and carbon dioxide between tissues and the lungs. Oxygenated blood is bright red, while oxygen-depleted blood is darker. It also carries...
The primary function of blood is to transport oxygen and carbon dioxide between tissues and the lungs. Oxygenated blood is bright red, while oxygen-depleted blood is darker. It also carries...
Composition of Blood
The blood in our bodies comprises three major components: blood plasma, formed elements, and the extracellular matrix. Blood plasma is a yellowish fluid that constitutes 55% of the total blood volume. It is primarily made up of water and essential substances such as electrolytes and proteins. Blood plasma serves as a medium for transporting blood cells and also contains nutrients, enzymes, hormones, antibodies, and gases.
Formed elements constitute the remaining 45% of the blood volume. These...
Formed elements constitute the remaining 45% of the blood volume. These...
Composition of Blood Plasma
Blood plasma is a fluid that contains approximately 92% water and 8% solutes. The solutes include various types of proteins, which constitute about 7% of the total solutes in the plasma. The high-molecular-weight proteins—albumins, globulins, and fibrinogen—are essential to plasma function. Albumins, making up about 60% of the plasma proteins, maintain the osmotic balance within blood vessels by preventing excessive water leakage. Additionally, albumins serve as carrier proteins, binding to...
Structure and Function of Leukocytes
An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
White blood cells protect the body...
Structure and Function of Platelets
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...

