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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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相关实验视频

Updated: Jul 10, 2026

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

一个诱导选择性T细胞分化的thymopoietin II片的化学合成.

D H Schlesinger, G Goldstein, M P Scheid

    Cell
    |August 1, 1975
    PubMed
    概括

    研究人员合成了一种thymopoietin,可以选择性地诱导T淋巴细胞的分化,类似于天然激素. 这一发现可以在小部分的胸腺素中确定关键的活性部位残留物.

    科学领域:

    • 免疫学 免疫学 免疫学
    • 生物化学 生物化学
    • 内分泌学 在内分泌学.

    背景情况:

    • 蒂莫波伊是一种来自甲状腺的多类激素,对免疫系统发育至关重要.
    • 了解蒂莫波伊的结构-活性关系是其治疗潜力的关键.

    研究的目的:

    • 为了合成一个特定的片段的thymopoietin.
    • 评估合成的生物活性和选择性.
    • 为了确定thymopoietin的活性部位残留物.

    主要方法:

    • 固态阶段合成 (梅里菲尔德技术).
    • 氨基酸分析和人工埃德曼降解用于序列验证.
    • 在体外测试以评估淋巴细胞分化诱导.

    主要成果:

    • 一个合成的 (位置29-41) 牛的thymopoietinII成功地合成了96%的纯度.
    • 合成可以选择性地诱导T淋巴细胞的分化,模仿thymopoietin的作用.
    • 这种在没有诱导补充受体 (CR+) B淋巴细胞分化的情况下表现出活性.

    结论:

    更多相关视频

    Preparation and Applications of Organotypic Thymic Slice Cultures
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    A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants
    10:44

    A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants

    Published on: August 9, 2019

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    Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

    Published on: April 16, 2015

    Preparation and Applications of Organotypic Thymic Slice Cultures
    10:10

    Preparation and Applications of Organotypic Thymic Slice Cultures

    Published on: August 6, 2016

    A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants
    10:44

    A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants

    Published on: August 9, 2019

  • 蒂莫波伊的生物活性关键残留物位于小片段内.
  • 合成代表了thymopoietin活性部位的很大一部分.
  • 完整的生物活动可能需要完整的胸腺素分子的三级结构.