在海中发现B型流感病毒
A D Osterhaus1, G F Rimmelzwaan, B E Martina
1National Influenza Center, Department of Virology, Erasmus University, Doctor Molewaterplein 50, 3015 GE Rotterdam, Netherlands.
Science (New York, N.Y.)
|May 12, 2000
概括
在海港海中发现了人类病原体B型流感病毒,这表明存在潜在的动物水库. 这一发现凸显了过去流传的菌株对人类健康的可能威胁.
科学领域:
- 病毒学 病毒学
- 海洋哺乳动物健康
- 动物传播疾病 动物传播疾病
背景情况:
- 作为人类重要病原体的B型流感病毒的起源和自然储存库仍然基本未知.
- 在全球范围内,B型流感病毒对公众健康构成持续威胁.
研究的目的:
- 调查B型流感病毒在非人类动物群体中传播的可能性.
- 为了确定以前在人类中传播过的B型流感病毒菌株的可能天然储存库.
主要方法:
- 从自然感染的港湾海 (Phoca vitulina) 中分离和表征B型流感病毒.
- 在体外感染性测定使用海细胞.
- 对海血清和病毒分离物的序列分析和血清学测试.
- 随着时间的推移收集的海血清样本的回顾性分析.
主要成果:
- 一种B型流感病毒 (B/Seal/Netherlands/1/99) 从一个海成功分离出来.
- 隔离的海流感B病毒在实验室中具有传染性,可以封闭细胞.
- 测序和血清学数据显示,海病毒与4-5年前的人类菌株密切相关.
- 在1995年以后采集的海的2%中检测到B型流感病毒的抗体,但在早期的样本中没有检测到.
结论:
- 港湾海可能充当B型流感病毒的储存库,藏以前在人类中传播过的菌株.
- 这些病毒在海中的存在对人类群体构成潜在的动物性传染病威胁.
- 需要进一步的研究,以了解B型流感病毒在海洋哺乳动物中的动态及其对公众健康的影响.
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