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青少年对环境热应激的血液动力学反应的种族差异
R M Kelsey1, B S Alpert, S M Patterson
1University of Tennessee College of Medicine, Memphis, USA. rkelsey@utmem.edu
Circulation
|May 16, 2000
概括
与白人青少年相比,黑人青少年对寒冷压力的心脏和血管收缩反应更强. 血管反应的这些差异可能会导致黑人人高血压风险.
科学领域:
- 心血管生理学心血管生理学
- 种族健康差异的差异
- 青少年健康 青少年健康
背景情况:
- 以前的研究表明,与白人儿童相比,黑人儿童对压力因素的血压 (BP) 反应更大.
- 这些BP反应性差异背后的特定心脏和血管机制仍然不清楚.
- 目前尚不清楚,血管反应的种族差异是否来自过度血管收缩或缺陷血管扩张.
研究的目的:
- 调查心脏和血管对血压反应性种族差异的贡献.
- 为了确定血管反应的种族差异是否涉及过度血管收缩或缺陷血管扩张.
主要方法:
- 在健康的黑人 (n=76) 和白人 (n=60) 青少年 (平均年龄14.8岁) 中,评估了血压,心率和阻力心脏图 (排泄前期[PEP]和总外周阻力[TPR]).
- 在被动暴露于冷 (8-10°C) 和热 (40-42°C) 室期间评估的反应.
- 利用协差分析来探索潜在的机制.
主要成果:
- 与白人青少年相比,黑人青少年在暴露于寒冷期间PEP的减少和TPR的增加更大 (P<0.05).
- 在暴露于热量期间,没有观察到响应的显著群体差异.
- 协差分析表明,在寒冷压力期间,黑人青少年的β-上腺体心脏和α-上腺体血管缩反应性更大.
结论:
- 黑人和白人青少年对热应激有类似的心肌和血管扩张反应.
- 黑人青少年表现出高心肌和血管收缩反应对寒冷的压力.
- 血管反应的种族差异似乎涉及血管收缩而不是血管扩张,这可能会导致黑人患高血压的风险.
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