在双胞胎怀孕中子宫内死亡的后果
1Department of Public Health, University of Liverpool, UK. p.o.d.pharoah@liv.ac.uk
Lancet (London, England)
|May 23, 2000
概括
在子宫中死亡的胎儿的幸存双胞胎面临更高的脑损伤风险,总体风险为20%. 这项研究量化了双胞胎幸存者面临的重大风险,突出了提高认识和监测的必要性.
科学领域:
- 周围生理学 周围生理学
- 新生儿科学 新生儿科学
- 流行病学 流行病学
背景情况:
- 与单独怀孕相比,双胞胎怀孕的死亡率和发病率风险更高.
- 在子宫中死亡的胎儿的幸存的双胞胎处于特别高的风险之中.
研究的目的:
- 量化对象经历了子宫内胎儿死亡的幸存双胞胎的死亡率和严重发病率.
- 评估在双胞胎在子宫内死亡后出生的婴儿中脑功能障碍的风险.
主要方法:
- 一项队列研究使用英格兰和威尔士 (1993-1995) 双胞胎出生数据进行.
- 死亡证明和全科医生问卷被用来收集关于幸存双胞胎死亡率和残疾的数据.
- 随访数据收集了在子宫内死亡的胎儿的活生生的双胞胎.
主要成果:
- 对于同性双胞胎,脑的患病率为每1000人中106人,其他脑功能障碍的患病率为每1000名婴儿幸存者中114人.
- 对于异性双胞胎,脑麻的患病率为每1000人中29人,其他脑功能障碍的患病率为每1000名婴儿幸存者中118人.
- 在子宫内胎儿死亡后,活生生的双胞胎的整体脑损伤风险为20%.
结论:
- 在子宫中死亡的胎儿的活生生的双胞胎对脑损伤的风险增加.
- 这些婴儿中脑的患病率明显高于一般双胞胎人口.
- 妊娠年龄特异性脑风险在子宫内同胞死亡后显著增加.
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