左心室顶部切除减少了脆弱性的上限
N Chattipakorn1, P C Fotuhi, X Zheng
1Division of Cardiovascular Disease, Department of Medicine, University of Alabama, Birmingham, USA. toon@crml.uab.edu
Circulation
|June 1, 2000
概括
在左心室顶部的向性切除显著降低了诱导心室动 (VF) 所需的电击强度. 这一发现表明,沉默这个特定的早期激活部位可以防止VF启动.
科学领域:
- 电子生理学 电子生理学
- 心血管研究研究心血管研究
- 医疗器械技术 医疗器械技术
背景情况:
- 电击后的左心室 (LV) 顶部的焦点激活通常会启动心室动 (VF) 诱导.
- 易受性的上限 (ULV50) 表示冲击强度,其诱导VF的概率为50%.
- 了解早期激活地点对于制定预防VF的策略至关重要.
研究的目的:
- 测试LV顶部的下内心切除,即早期激活部位,是否会降低ULV所需的冲击强度 (50).
- 调查切除这个特定部位对VF诱导值的影响.
主要方法:
- 在猪中使用上/下协议与T波扫描确定ULV(50).
- 在5头猪身上在LV顶部进行了心内射频除.
- 经过切除后重复确定ULV ((50) 并将结果与另外5头猪的LV基切除进行比较.
主要成果:
- 对于ULV,LV顶部除显著降低了输送电压 (19%) 和能量 (34%).
- 在LV基除后,没有观察到ULV(50) 的显著差异.
- 在两个切除位点都始终实现了心下内脏病变.
结论:
- 在顶端LV的下内心切除显著降低ULV{50}.
- 在LV顶部的早期后冲击激活对于VF启动至关重要.
- 电静止这个部位为管理VF诱导提供了一个潜在的治疗策略.
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