左心室同心重塑而不是左心室缩与老年男性的胰岛素抵抗综合征有关
J Sundström1, L Lind, N Nyström
1Department of Public Health, Uppsala University, Sweden. Johan.Sundstrom@geriatrik.uu.se
Circulation
|June 7, 2000
概括
在老年男性中,胰岛素抵抗综合征的组成部分与较厚的左心室 (LV) 壁和同心重塑有关,而不是LV缩. 这项研究在大量人口样本中探索了这些关联.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征研究 代谢综合征研究
- 老年医学 老年医学
背景情况:
- 之前关于左心室 (LV) 几何和胰岛素抵抗综合征的研究仅限于中年高血压患者的较小组.
- 胰岛素抵抗综合征是一组增加心血管疾病风险的代谢异常.
研究的目的:
- 研究左心室 (LV) 几何和胰岛素抵抗综合征的组成部分之间的关联.
- 利用基于人口的大型老年男性样本进行综合分析.
主要方法:
- 心声图被用来评估475名老年男性 (157名高血压患者) 的LV几何状况.
- 进行了口服葡萄糖耐受性测试 (OGTT),高胰岛素高血糖,脂质概况和24小时的门诊血压监测.
- 统计分析检查了LV几何参数 (相对壁厚,质量指数) 和代谢/血液动力学因素之间的关系.
主要成果:
- LV相对壁厚与胰岛素敏感性相关,禁食胰岛素,甘油三,脂肪酸,OGTT葡萄糖和胰岛素水平,腰比,体重指数,24小时血压和心率.
- LV 质量指数与 24 小时内压, 2 小时的 OGTT 胰岛素和心率有显著的关系.
- 与正常 LV 几何相比,集中式重塑与更高的 24 小时心率,高 OGTT 葡萄糖和胰岛素,增加腰部和部比率,更高的体重指数和更低的紧胰岛素敏感度指数有关.
结论:
- 在老年男性中,胰岛素抵抗综合征的组成部分与增加LV壁厚度和同心重塑有关.
- 这些代谢因素与此种人群的 LV 缩不太相关.
- 研究结果强调了老年男性代谢健康和心脏结构变化之间的联系.
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