口服未分离的肝素与载体剂是治疗深静脉血栓的治疗方法
M D Gonze1, K Salartash, W C Sternbergh
1Department of Surgery, The Ochsner Medical Institutions, New Orleans, LA, USA.
Circulation
|June 7, 2000
概括
口服氨酸与SNAC结合有效治疗大鼠的深静脉血栓塞 (DVT),显示与低分子量氨酸相似的结果. 这种新的口服配方为DVT治疗提供了一个有希望的替代方案.
科学领域:
- 药理学 药理学是指药理学的学科.
- 血栓形成研究研究
- 药物输送系统 药物输送系统
背景情况:
- 口服肝素 (OHEP) 具有较差的生物利用性,限制了其治疗疗效.
- N-(8[2-基]氨基) 酸 (SNAC) 是一种用于胃肠道药物输送的吸收增强剂.
- 研究了OHEP和SNAC (OHEP/SNAC) 的组合,用于深静脉血栓塞 (DVT) 治疗.
研究的目的:
- 为了评估OHEP/SNAC在DVT的老鼠模型中的疗效.
- 为了比较OHEP/SNAC与现有肝素配方和对照剂的有效性.
主要方法:
- 在Sprague-Dawley大鼠中诱导了深静脉血栓形成.
- 动物接受了7天的各种药物治疗:未经处理的对照剂,皮下肝素 (SC HEP),仅SNAC,仅OHEP,低分子量肝素 (LMWH) 和OHEP/SNAC.
- 测量了激活的部分血栓形成时间 (aPTT) 和抗X因子 (anti-Xa) 水平.
主要成果:
- OHEP/SNAC和LMWH显著降低了残留DVT的发生率 (10%对比100%控制,P<0.001).
- 与对照组相比,OHEP/SNAC和LMWH都显示出凝块重量的显著降低.
- 与其他组相比,OHEP/SNAC在药物后显示出明显更高的aPTT和高抗Xa水平.
结论:
- 在大鼠模型中,OHEP/SNAC在治疗DVT方面表现出显著的疗效.
- 将OHEP与载体SNAC结合使用,可以达到与LMWH相当的治疗效果.
- 这项研究强调了SNAC作为口服肝素输送的载体在管理DVT方面的潜力.
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