老年人的夜间多尿尿与基本高血压的关系
1London School of Hygiene and Tropical Medicine, UK. paul.mckeigue@lshtm.ac.uk
Lancet (London, England)
|June 7, 2000
概括
在老年人中常见的夜间多尿症,涉及逆向的尿液产生. 这种情况与高血压有关,可能源于氧化通路缺陷.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 老年学是一门学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 夜间多尿,以增加夜间尿液产生为特征,在老年人中很普遍.
- 它经常被误诊和治疗不当,如男性前列腺手术.
- 夜间多尿症与夜尿症和基本高血压有关.
研究的目的:
- 在老年人中调查夜间多尿症的病理生理学.
- 探索夜间多尿和基本高血压之间的关系.
- 为他们的共同决定因素提出一个统一的假设.
主要方法:
- 在夜间多尿症的老年患者中对夜间分泌和自由水清除的比较分析与对照.
- 审查关于夜间多尿症,夜尿症和基本高血压的现有文献.
- 基于病理生理学联系的假设生成.
主要成果:
- 与对照组相比,夜间多尿症的老年患者夜间分泌量较高.
- 在患者和对照组之间,夜间自由水清除没有显著差异.
- 夜间多尿症在不同年龄段始终与高血压有关.
结论:
- 由于潜在的危害,不建议使用瓦索普雷辛类似物治疗夜间多尿症;利尿剂治疗是一种更安全的替代方案.
- 夜间多尿症和基本高血压可能具有共同的病理生理机制.
- 假设氧化通路的缺陷有助于这两种情况,涉及改变的压力-化和处理.
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