全球冠状动脉流量和流量储备的基于磁共振的评估及其与左心室功能参数的关系:与正子发射断层扫描的比较
J Schwitter1, T DeMarco, S Kneifel
1Division of Cardiology, University Hospital Zurich, Switzerland. karscz@usz.unizh.ch
Circulation
|June 14, 2000
概括
阶段对比磁共振成像准确地测量了冠状动脉鼻血流,使冠状动脉血液动力学和适合患者监测的综合评估. 这种技术对于评估冠状动脉流量储备有价值.
科学领域:
- 心血管成像 - 心血管成像
- 非侵入性的血液动力学.
- 磁共振成像技术 磁共振成像技术
背景情况:
- 使用相对比磁共振 (PC-MR) 成像测量冠状动脉鼻腔血流 (CSF) 为评估全球冠状动脉血液动力学提供了一种非侵入性方法.
- 评估静止和高血压期间的冠状动力学对于了解心脏功能至关重要.
研究的目的:
- 验证PC-MR成像用于测量冠状动脉鼻腔血流 (CSF) 和冠状动脉流量储备 (CFR) 的使用.
- 为了比较PC-MR衍生的流量数据与正子发射断层扫描 (PET) 测量.
- 评估CSF和心肌氧气需求之间的关系.
主要方法:
- 16名健康的志愿者接受了MRI和PET成像.
- 冠状动脉鼻腔血流 (CSF) 用 cine PC-MR 测量静止状态和药理性高血压 (二皮里达摩尔) 期间.
- 心肌动脉血流量 (MBF) 使用[(13) N]NH(3) PET.测量.
主要成果:
- 脊髓的PC-MR测量显示与PET衍生MBF对冠状动脉流量储备 (CFR) 的密切一致.
- 以左心室质量 (LVM) 或排出心肌量 (LVM) 规范化的CSF与PET数据和氧气需求的测量高度相关.
- 在心脏移植接受者中,CFR降低,休息时流量的增加有助于这种降低.
结论:
- 综合MR方法提供了对自我调节和高血压冠状动脉流的全面评估.
- 这种PC-MR技术适用于患者的连续测量,包括心脏移植患者.
- 休息时流量的增加被认为是心脏移植患者心率降低的主要因素.
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