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Human Blastocyst Biopsy and Vitrification
Published on: July 26, 2019
英国生物生育的时间趋势
1Department of Epidemiology and Public Health, Imperial College School of Medicine, London, UK. m.jofe@ic.ac.uk
Lancet (London, England)
|June 20, 2000
概括
与对精液质量下降的担忧相反,这项研究发现,近几十年来,英国夫妇的生育率实际上有所增加. 使用时间到怀孕数据观察到这种趋势,表明生物生育能力有所改善.
科学领域:
- 生殖健康 生殖健康
- 人类生育能力研究 研究人类生育能力
- 流行病学 流行病学
背景情况:
- 有证据表明,某些国家的精液质量正在下降,这促使对生物生育能力潜在下降的调查.
- 以前的假设表明生育率下降反映了精液质量趋势.
- 怀孕的时间 (TTP) 是评估生育趋势的验证指标.
研究的目的:
- 调查英国生物生育能力下降的假设.
- 用时间到怀孕 (TTP) 数据评估夫妇生育率的趋势.
- 分析与特定时间段和出生队伍相关的生育趋势.
主要方法:
- 在一个代表性英国人口样本 (16-59岁) 上进行了一项回顾性队列研究.
- 时间到怀孕 (TTP) 数据收集了1961-1993年间怀孕的分娩,不包括避孕失败.
- 分析了1540个人的样本大小.
主要成果:
- 该研究发现,夫妇生育率的趋势越来越高,这与最初的假设相矛盾.
- 生育率趋势在男性和女性受访者中显示出一致性,并且对混因素具有强大影响.
- 与伴侣出生年份 (队列效应) 相比,与无保护性交的开始年份 (周期效应) 观察到更强的关联.
结论:
- 观察到的生育率的增加不能归因于第一次出生时的年龄变化,不孕症治疗或口服避孕药的使用.
- 任何男性生育能力的潜在下降似乎都被整体夫妇生育能力的增加所抵消.
- 这些发现表明,随着时间的推移,影响生殖成功的因素的复杂相互作用.
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