心血管疾病死亡率在家族形式的高甘油三血症:一个20年的前性研究
M A Austin1, B McKnight, K L Edwards
1Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195-7236, USA. maustin@u.washington.edu
Circulation
|June 22, 2000
概括
家庭组合性高脂血症 (FCHL) 家庭的亲属面临更高的心血管疾病 (CVD) 死亡风险. 高水平的甘油三预测家族性高甘油三血症 (FHTG) 家庭中的心血管疾病死亡,强调了预防的必要性.
科学领域:
- 心血管流行病学心血管流行病学
- 脂肪代谢障碍 脂肪代谢障碍 脂肪代谢障碍
- 对心血管疾病的遗传倾向.
背景情况:
- 家庭结合性高脂血症 (FCHL) 和家庭高甘油三血症 (FHTG) 是常见的遗传性脂质疾病.
- 关于这些家庭内心血管疾病 (CVD) 风险的前性数据有限.
- 了解长期死亡风险对于有针对性的干预至关重要.
研究的目的:
- 估计FCHL和FHTG试验对象的FCHL和FHTG亲属的20年总和心血管疾病死亡风险.
- 评估血甘油三水平作为这些家族高脂血症队伍中死亡率的预测指标.
- 为制定有效的心脏病预防策略提供信息.
主要方法:
- 来自101个家庭的脂质和病史数据的前性队列研究.
- 从1993年至1997年,确定了685名家庭成员 (亲属和配偶控制) 的生命状况和死亡原因.
- 对基线共变量进行调整的统计分析,以确定相对风险.
主要成果:
- 在FCHL家庭的兄弟姐妹和后代中观察到20年心血管疾病死亡风险增加了1.7倍 (P=0.02).
- 在FHTG家族中,没有发现心血管疾病死亡风险的统计显著增加 (RR=1.7,P=0.39).
- 升高的基线甘油三水平预测了FHTG家族中心血管疾病死亡率 (RR=2.7,P=0.02),独立于总胆固醇.
结论:
- 在FCHL家族中的亲属表现出显著增加心血管疾病死亡率的风险.
- 基线甘油三水平是FHTG家族中心血管疾病死亡率的重要预测指标.
- 这些发现强调了高甘油三血症作为心血管疾病风险因素的重要性以及需要采取预防措施的必要性.
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