心力衰竭中呼吸系统效率的降低:预后影响的预后
F X Kleber1, G Vietzke, K D Wernecke
1Medizinische Klinik und Poliklinik I, Universitätsklinikum Charité, Arbeitsgruppe Medizinische Biometrie, Humboldt-Universität zu Berlin, Berlin, Germany. franz-xaverk@ukb.de
Circulation
|June 22, 2000
概括
VE与V ((CO ((2)) 的斜率有效预测了充血性心力衰竭 (CHF) 患者的存活率. 较低的斜率表明更好的无事件生存率,超过VO(2) max作为预后标志物.
科学领域:
- 心脏病学 心脏病学
- 肺部医学 肺部医学
- 运动生理学 运动生理学
背景情况:
- 在充血性心力衰竭 (CHF) 中,呼吸系统效率下降与症状和呼吸障碍有关.
- 了解预后标志物对于管理CHF患者至关重要.
研究的目的:
- 为了评估呼吸器效率的预后意义,特别是 VE 与 V ((CO ((2)) 倾斜率,在CHF患者中.
- 为了比较 VE 与 V ((CO ((2)) 倾斜率的预测能力与其他已确定的参数,如 VO ((2) max.
主要方法:
- 对142名心肺衰竭患者和101名健康对照进行了心肺运动测试.
- 风机效率被量化为 VE 与 V ((CO ((2)) 关系的斜率.
- 通过跟踪不良事件 (死亡,移植,设备植入) 来评估预后价值.
主要成果:
- 在评估的参数中,VE与V ((CO ((2)) 的斜率是无事件生存的最强预测因素.
- 与正常值≤130%的VE与V (((CO(2)) 斜率相比,与斜率>130% (54.7%) 的患者相比,患者在1年无事件生存率 (88.3%) 显著更好.
- 这一参数被证明比VO2max,NYHA类,LVEF,肺总容量和年龄更有影响力.
结论:
- 在CHF中,VE与V (((CO(2)) 倾斜率是一个非常有效的预后参数.
- 这种测量比最大运动能力指标更容易获得.
- 在CHF中预测结果时,VE与V (CO) 倾斜率比VO (max) 倾斜率具有更大的预后重要性.
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