广谱防晒的使用和白色儿童新瘤的发展:一项随机对照试验
R P Gallagher1, J K Rivers, T K Lee
1Cancer Control Research Program, British Columbia Cancer Agency, 600 W Tenth Ave, Vancouver, British Columbia, Canada V5Z 4E6. rickg@bccancer.bc.ca
JAMA
|June 24, 2000
概括
使用广谱防晒显著减少了白色儿童新的发展. 这种效应在有雀斑的儿童中尤为明显,这表明防晒在预防黑色素瘤风险因素方面起着关键作用.
科学领域:
- 儿科皮肤病学 儿科皮肤病学
- 预防医学 预防医学
- 在瘤学瘤学.
背景情况:
- 高密度的黑色细胞瘤是皮肤恶性黑色素瘤的已知危险因素.
- 神经的发育,特别是在儿童中,与阳光照射密切相关.
- 早期干预策略对于减轻黑色素瘤风险至关重要.
研究的目的:
- 调查广谱,高阳光保护因子 (SPF) 防晒在预防神经瘤发展方面的有效性.
- 为了确定防晒的使用是否可以减轻白色儿童新形的形成.
- 评估防晒对黑色素瘤的一个关键风险因素的影响.
主要方法:
- 一个随机对照试验,涉及309名白人学童 (1至4年级) 在不列颠哥伦比亚省温哥华.
- 干预组 (n=222) 接受了SPF 30广谱防晒,而对照组 (n=236) 没有得到防晒或建议.
- 在基线和3年后,新瘤的数量被列举,新瘤的获取与不同组之间的比较.
主要成果:
- 与对照组相比,使用防晒的儿童的新瘤数量显著减少 (中位数为24对28,P=.048).
- 观察到雀斑和研究组之间存在显著的相互作用,突出显示雀斑儿童的益处更大.
- 建模表明,使用防晒的斑点儿童可以在新发育方面减少30%至40%.
结论:
- 广谱防晒显示出在减弱白色儿童神经发育方面的潜力.
- 防晒的保护作用对有雀斑的儿童尤为重要.
- 持续使用防晒可能是减少童年黑色素瘤风险因素的有效策略.
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