通过哺乳动物吐口鼻神经元进行超敏感的费洛蒙检测
T Leinders-Zufall1, A P Lane, A C Puche
1Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore 21201, USA.
Nature
|June 24, 2000
概括
吐口鼻子器官 (VNO) 具有显著的灵敏度检测激素,激活特定的神经元. 这项研究阐明了这些化学信号如何调节哺乳动物的沟通和生殖行为.
科学领域:
- 神经科学是一个神经科学.
- 感官生物学 感官生物学
- 哺乳动物繁殖 哺乳动物繁殖
背景情况:
- 吐口鼻子器官 (VNO) 对于检测激素至关重要,影响哺乳动物的性和生殖功能.
- 费洛蒙信号转导由鼻神经元的精确机制尚未完全理解.
研究的目的:
- 为了研究由鼻神经元检测费洛蒙的特征.
- 为了阐明vomeronasal神经元对特定费洛蒙的反应的敏感性和选择性.
主要方法:
- 使用小鼠VNO切片制备用于电生理学记录.
- 采用共聚焦成像来绘制VNO表皮中的神经元激活模式.
- 测试了单个吐口鼻神经元对六个假定费洛蒙的反应.
主要成果:
- 吐口神经元对费洛蒙表现出激发性反应,产生动作潜力并增加细胞内.
- 对一些费洛蒙的检测值非常低 (接近10~11M).
- 揭示了每个激素激活在上皮质的独特,不重叠的vomeronasal神经元子集,具有高度选择性的调特性.
结论:
- 吐口鼻神经元是高度敏感的化学检测器,对于激素信号处理至关重要.
- 鼻神经元的特定激活模式和选择性调整为了解哺乳动物化学通信和性行为提供了基础.
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