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相关概念视频

Genomics02:02

Genomics

35.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.5K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

11.8K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
11.8K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

16.7K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
16.7K
Ribosome Profiling02:24

Ribosome Profiling

3.2K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.2K
The Central Dogma01:20

The Central Dogma

21.2K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
21.2K
Proteomics01:33

Proteomics

7.5K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.5K

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相关实验视频

Updated: May 2, 2026

Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
12:04

Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing

Published on: October 3, 2018

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在后基因组时代的蛋白质功能.

D Eisenberg1, E M Marcotte, I Xenarios

  • 1Molecular Biology Institute and UCLA-DOE Laboratory of Structural Biology and Molecular Medicine, University of California at Los Angeles, 90095-1570, USA. david@mbi.ucla.edu

Nature
|June 24, 2000
PubMed
概括
此摘要是机器生成的。

功能性基因组学旨在将庞大的基因组数据转化为生物知识. 这个字段涉及如何将序列和信使RNA表达数据合成有意义的见解.

更多相关视频

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

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An Integrated Approach for Microprotein Identification and Sequence Analysis
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相关实验视频

Last Updated: May 2, 2026

Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
12:04

Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing

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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

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An Integrated Approach for Microprotein Identification and Sequence Analysis
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An Integrated Approach for Microprotein Identification and Sequence Analysis

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科学领域:

  • 基因组学就是基因组学.
  • 分子生物学分子生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 生物研究正在产生大量的基因组和信使RNA (mRNA) 表达数据.
  • 挑战在于将这种数据洪水转化为可操作的科学知识.
  • 当前的数据处理方法很难有效地合成各种生物信息.

研究的目的:

  • 探索功能基因组学的新兴领域.
  • 为了解决如何从广泛的基因组和表达数据中获得有意义的知识这一关键问题.
  • 定义功能基因组学产生的知识的潜在形式和应用.

主要方法:

  • 对基因组数据生成当前趋势的分析.
  • 对高通量表达式分析技术 (例如微阵列) 的审查.
  • 生物学知识综合学的概念框架开发.

主要成果:

  • 确定了生物学数据生成和知识获取之间的重大差距.
  • 强调需要新的方法来整合和解释复杂的生物数据集.
  • 建立功能性基因组学作为应对这一挑战的关键学科.

结论:

  • 功能性基因组学提供了一条将大规模生物数据转化为生物理解的途径.
  • 对基因组和表达数据的有效合成对于推动生物发现至关重要.
  • 该领域有望重塑生物知识的产生和利用方式.