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相关概念视频

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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相关实验视频

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An Aquatic Microbial Metaproteomics Workflow: From Cells to Tryptic Peptides Suitable for Tandem Mass Spectrometry-based Analysis
08:09

An Aquatic Microbial Metaproteomics Workflow: From Cells to Tryptic Peptides Suitable for Tandem Mass Spectrometry-based Analysis

Published on: September 15, 2015

蛋白质组学用于研究基因和基因组.

A Pandey1, M Mann

  • 1Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142, USA.

Nature
|June 24, 2000
PubMed
概括

蛋白质组学是对蛋白质的大规模研究,有助于理解基因功能. 它涉及蛋白质识别,差异显示和相互作用研究,为生物和疾病研究提供了重大前景.

科学领域:

  • 生物化学 生物化学
  • 分子生物学分子生物学
  • 基因组学就是基因组学.

背景情况:

  • 后基因组时代需要先进的方法来理解基因功能.
  • 蛋白质分析或蛋白质组学对于阐明生物过程至关重要.
  • 仅从序列或结构来预测蛋白质功能可能是具有挑战性的.

研究的目的:

  • 突出蛋白质组学在理解基因功能的重要性.
  • 概述蛋白质组学的关键领域和应用.
  • 强调蛋白质组学在功能性蛋白质组分析中的潜力.

主要方法:

  • 用于大规模蛋白质识别和修改分析的蛋白质微型表征.
  • 差异显示蛋白质组学用于比较蛋白质表达水平.
  • 蛋白质与蛋白质相互作用的研究采用诸如质谱学和酵母双混合系统等技术.

主要成果:

  • 蛋白质组学为蛋白质分析提供了一种多方面的方法.
  • 不同显示蛋白质组学在疾病研究中具有潜在的应用.
  • 识别蛋白质复合体的组成部分是功能蛋白质组分析的核心.

结论:

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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

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An Aquatic Microbial Metaproteomics Workflow: From Cells to Tryptic Peptides Suitable for Tandem Mass Spectrometry-based Analysis
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An Aquatic Microbial Metaproteomics Workflow: From Cells to Tryptic Peptides Suitable for Tandem Mass Spectrometry-based Analysis

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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

  • 蛋白质组学是促进我们对生物系统的理解的重要领域.
  • 蛋白质复合体和细胞结构的研究具有显著的前景.
  • 蛋白质组学将大大有助于对蛋白质生物化学,过程和通路的理解.