在子模型中,心力衰竭与心室节律失常和突然死亡的节功能发生变化
T Opthof1, R Coronel, H M Rademaker
1Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands. t.opthof@med.uu.nl
Circulation
|June 28, 2000
概括
心力衰竭会改变自主神经系统的平衡. 这项研究发现,心力衰竭中的内在鼻结功能变化不能解释心率变化降低,这表明其他机制参与其中.
科学领域:
- 心脏病学 心脏病学
- 自主神经系统生理学 自主神经系统生理学
- 心脏衰竭病理生理学 病理生理学
背景情况:
- 心力衰竭显著影响自主神经系统的平衡,其特征是阴道抽出和高水平的类甲醇胺.
- 在心力衰竭进展期间内在鼻结功能的具体变化仍然不清楚.
研究的目的:
- 在心力衰竭的进展过程中调查内在鼻结功能变化.
- 确定内在鼻结功能障碍是否有助于降低心率变化和心力衰竭中的巴罗反射灵敏度.
主要方法:
- 利用心力衰竭的子模型 (n=9) 和霍尔特监测来评估体内鼻周期长度和心律失常.
- 在实验室中对隔离的右心室进行了分析 (12只心力衰竭子,6只对照动物),以评估鼻循环的长度和对乙胆和北上腺素的反应.
主要成果:
- 在体内,鼻腔循环长度显示出可变的变化;在循环长度较短的3/9只子中发生了突然死亡.
- 在心力衰竭的子中,心室性心力衰竭很普遍.
- 试管体内研究显示,心力衰竭时,鼻腔循环长度增加,对乙胆的反应增强,与北上腺素反应不变.
结论:
- 在心力衰竭中,内在鼻节功能变化并不能解释心率变化或巴罗反射灵敏度的降低.
- 观察到对乙胆的反应增加表明一种补偿机制,而不是减少心率变化的原因.
相关概念视频
01:19Electrophysiology of Normal Cardiac Rhythm
7.8K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
7.8K
01:28Mechanism of Cardiac Arrhythmias
2.8K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
2.8K