在一般人群中,血清溶解热冲击蛋白60在动脉样硬化患者中升高
1Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck. qingbo.xu@oeaw.ac.at
Circulation
|July 6, 2000
概括
高水平的可溶性热冲击蛋白60 (sHSP60) 与动脉样硬化有关. 这一发现表明sHSP60可能在血管炎症和疾病发展中发挥作用.
科学领域:
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
- 分子生物学分子生物学
背景情况:
- 以前的研究将抗热冲击蛋白60 (HSP60) 抗体和HSP60反应T细胞与动脉样硬化联系在一起.
- 已经证明HSP60可以直接激活内皮细胞和巨细胞,这些细胞是血管疾病的关键参与者.
研究的目的:
- 调查循环溶性HSP60 (sHSP60) 在动脉样硬化中的存在和作用.
- 为了确定sHSP60水平是否与动脉动脉样硬化和相关的危险因素相关.
主要方法:
- 一项以人口为基础的研究,涉及826名年龄在40-79岁之间的受试者.
- 测量血清sHSP60,各种抗体 (抗脂多糖,抗HSP65,抗克拉米迪亚,抗Helicobacter pylori),急性相反应物和全身炎症标志物.
- 评估动脉样硬化 (1990年和1995年) 和其他15个危险因素.
主要成果:
- 在患有流行和发病性动脉样硬化症的受试者中,血清sHSP60水平显著升高.
- sHSP60水平与常见的动脉内心/中枢厚度相关,独立于传统的危险因素.
- sHSP60与炎症标志物,慢性感染和特异性抗体有关,在感染者中增加了动脉样硬化风险.
结论:
- 这项研究提供了第一个证据,表明sHSP60与动脉样硬化之间存在强烈的相关性.
- sHSP60通过激活血管细胞和免疫系统,可能会导致动脉样硬化.
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