冠状动脉的流速与灯膜面积和区域左心室质量有关
H V Anderson1, M J Stokes, M Leon
1University of Texas Health Science Center and Hermann Hospital, Houston 77225, USA. skipand@heart.med.uth.tmc.edu
Circulation
|July 6, 2000
概括
静止冠状动脉流速与心脏的大小有关.
科学领域:
- 心血管生理学心血管生理学
- 冠状动脉疾病 冠状动脉疾病
- 血液动力学 血液动力学
背景情况:
- 冠状动脉流速在静止状态下表现出显著的个体间变化.
- 冠状动脉流量储备 (高血压与静止速度的比率) 是一个常被研究的指数.
- 研究了流量连续性原理,用于建模静止冠状动脉流量.
研究的目的:
- 为了测试这一假设,即流量连续性原理可以模拟静止冠状动脉流.
- 为了检查冠状动脉灯光大小和静止速度之间的关系.
- 为了研究冠状动脉样硬化对静止流动力学的影响.
主要方法:
- 多普勒线用于测量59名患者的静止和高血压速度.
- 量化计算光线的横截面积和远端冠状动脉分支的长度.
- 估计区域左心室质量和流明面积与质量比 (A/m).
主要成果:
- 休息速度 (V) 与A/m比率 (V=46.5/(A/m)) 有一个反向关系.
- 随着左前下降动脉疾病的严重程度增加,A/m比率下降.
- 休息平均峰值速度倾向于增加更严重的冠状动脉样硬化.
结论:
- 静止冠状动脉的流速与面积与区域左心室质量比率相反.
- 升高的静止速度表明心肌床的光量不足,这在扩散性冠状动脉样硬化中是典型的.
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