在不同的心房动实验模型中对比多菲提利德的疗效
1Research Center and Department of Medicine, Montreal Heart Institute Quebec, Canada.
Circulation
|July 6, 2000
概括
在充血性心力衰竭 (CHF) 模型中,多菲提利德有效治疗心房动 (AF),但在快速心房节奏 (RAP) 模型中效果较差. AF机制显著影响抗心律失常药物的疗效.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 电子生理学 电子生理学
背景情况:
- 心房动 (AF) 可以由不同的实验条件诱导,包括快速心房节奏 (RAP) 和充血性心力衰竭 (CHF).
- 这些不同的基质可能会影响抗心律失常药物治疗的有效性.
研究的目的:
- 为了调查由不同的基质 (RAP与CHF) 维持的AF是否对III类抗心律不良药多菲提利德有不同的反应.
- 了解AF中差异性药物反应的机制基础.
主要方法:
- 在狗中,AF通过7天的RAP或快速心室节奏来诱导CHF.
- 多菲提利德被静脉注射为两剂 (10和80微克/公斤).
- 脊柱心脏映射用于分析AF机制和药物效应.
主要成果:
- 多菲提利德成功地终止了所有CHF狗的AF.
- 在RAP犬中,多菲提利德的有效性显著下降,在高剂量 (P<0.01) 的情况下,仅在20%的病例中终止了AF.
- 在CHF犬中,多菲提利德增加了心房折射率和AF周期长度,主要是通过阻断宏入路电路,而在RAP犬中,它只减缓了多波小波的重新进入.
结论:
- AF的潜在机制是多菲提利德疗效的关键决定因素.
- 这些发现强调了基底特异性方法在抗失常药物开发和治疗中的重要性.
- 这可能解释了长期AF观察到的治疗阻力.
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