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Studying Mitotic Checkpoint by Illustrating Dynamic Kinetochore Protein Behavior and Chromosome Motion in Living Drosophila Syncytial Embryos
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在缺乏线粒检查点蛋白 Mad2 的小鼠中,染色体误分和亡

M Dobles1, V Liberal, M L Scott

  • 1Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.

Cell
|July 13, 2000
PubMed
概括

螺旋组装检查点蛋白 Mad2 对于小鼠细胞中精确的染色体分离至关重要. 它的缺失导致细胞分裂和胚胎死亡的错误,突显了它在防止线粒学灾难方面的重要性.

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Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...