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Updated: May 5, 2026

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
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Published on: January 29, 2018

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对Mdm2的SUMO-1修改阻止了其自我无处置,并增加了Mdm2对p53无处置的能力

T Buschmann1, S Y Fuchs, C G Lee

  • 1Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, New York 10029, USA.

Cell
|July 13, 2000
PubMed
概括

在Lys-446的Mdm2 E3无素酶化对p53调节至关重要. 降低Mdm2相化增强了p53稳定性和DNA损伤后的亡.

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