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Updated: Aug 14, 2026

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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对糖原合成酶激酶-3β在细胞存活和NF-kappaB激活中的要求

K P Hoeflich1, J Luo, E A Rubie

  • 1Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Canada.

Nature
|July 14, 2000
PubMed
概括

糖原合成酶激酶-3β (GSK-3β) 缺乏导致由于过度瘤坏死因子 (TNF) 毒性导致肝损伤的胚胎死亡. GSK-3β促进核因子-kappaB (NF-kappaB) 功能,防止TNF诱导的细胞死亡.

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