机械卸载与神经幽默刺激对心肌结构和内分泌功能的影响 In vivo
O Lisy1, M M Redfield, S Jovanovic
1Division of Cardiovascular Diseases, Departments of Internal Medicine and Physiology, Mayo Clinic and Foundation, Rochester, MN, USA. lisy.ondrej@mayo.edu
Circulation
|July 19, 2000
概括
慢性心脏卸载导致心肌缩和心房 natriuretic (ANP) 合成减少,尽管增加了神经幽默刺激. 这项研究澄清了机械负荷.
科学领域:
- 心血管生理学心血管生理学
- 心脏内分泌学心脏内分泌学
背景情况:
- 机械负荷和幽默因子,如内甲蛋白 (ET) 和血管素II (Ang II),显著影响心脏结构和功能.
- 耳前 natriuretic (ANP) 基因表达,产生和释放是由这些刺激调节的.
- 了解机械卸载和神经道激活在ANP之间的相互作用至关重要.
研究的目的:
- 研究慢性机械卸载对心肌和循环ANP水平的影响.
- 为了比较机械卸载与神经道刺激 in vivo 的效果.
- 阐明胸下静脉缩 (TIVCC) 在调节心脏ANP中的作用.
主要方法:
- 胸下静脉缩 (TIVCC) 在狗身上进行了10天,以诱导慢性心肌卸载.
- 评估了血液动力学参数,血ET和Ang II水平以及心肌标志物.
- 分析了左心室 (LV) 质量,肌细胞尺寸,心房ANP储量,血ANP和ANP基因表达.
主要成果:
- TIVCC导致心脏输出量降低,右心房压和LV终端-透气直径.
- 观察到显著的血和心肌ET和AngII的激活.
- 尽管神经道激活,但LV质量和肌细胞直径下降 (缩),心房ANP储量增加,但血ANP和基因表达没有显著变化.
结论:
- 心脏的慢性机械卸载导致心肌缩.
- 尽管有ET和AngII的显著神经幽默刺激,但ANP的合成和释放没有被激活.
- 机械卸载取代了关于ANP调节的强有力的促进生长的神经幽默信号.
相关概念视频
01:29Pathophysiology of Cardiac Performance
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...