Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Multimodal Biomarkers That Predict the Presence of Gleason Pattern 4: Potential Impact for Active Surveillance.

The Journal of urology·2023
Same author

Crystal structure of a prokaryotic replication initiator protein bound to DNA at 2.6 Å resolution.

The EMBO journal·2022
Same author

Effect of Transluminal Injection of Foam Sclerotherapy Combined With Endovenous Thermal Ablation of Varicose Veins.

Journal of vascular surgery. Venous and lymphatic disorders·2020
Same author

Nightlife clusters of coronavirus disease in Tokyo between March and April 2020.

Epidemiology and infection·2020
Same author

Pathological role of excessive DNA as a trigger of keratinocyte proliferation in psoriasis.

Clinical and experimental immunology·2020
Same author

Phase I/II clinical trial to assess safety and efficacy of intratumoral and subcutaneous injection of HVJ-E in castration-resistant prostate cancer patients.

Cancer gene therapy·2017

相关实验视频

Updated: May 3, 2026

Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model
11:49

Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

Published on: September 9, 2011

23.1K

可生物降解的poly-l-乳酸冠状动脉支架在人类的初始和6个月结果.

H Tamai1, K Igaki, E Kyo

  • 1Department of Cardiology, Shiga Medical Center for Adults, Shiga, Japan.

Circulation
|July 25, 2000
PubMed
概括

可生物降解的聚-l-乳酸 (PLLA) 支架在冠状动脉手术中表现有前途. 这项研究发现PLLA支架是可行的,安全和有效的,患者的复原率较低.

更多相关视频

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

4.9K
Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access
05:04

Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access

Published on: November 19, 2020

4.0K

相关实验视频

Last Updated: May 3, 2026

Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model
11:49

Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

Published on: September 9, 2011

23.1K
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

4.9K
Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access
05:04

Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access

Published on: November 19, 2020

4.0K

科学领域:

  • 心血管医学 心血管医学
  • 生物材料科学 生物材料科学
  • 干预心脏病学 干预心脏病学

背景情况:

  • 金属支架是冠状动脉血管形成术的标准,但有局限性.
  • 可生物降解的聚-l-乳酸 (PLLA) 支架提供了潜在的优势,如局部药物输送.
  • 对金属支架的担忧需要对替代设备进行评估.

研究的目的:

  • 评估在冠状动脉干预中使用聚1乳酸 (PLLA) 支架的可行性,安全性和有效性.
  • 评估Igaki-Tamai PLLA支架在人类受试者的性能.
  • 将PLLA支架结果与现有的金属支架数据进行比较.

主要方法:

  • 15名患者接受了Igaki-Tamai PLLA支架的选择性植入,用于冠状动脉狭窄.
  • 由PLLA单聚合物制成的PLLA支架,带有状螺旋线圈,通过气球可扩展的覆盖进行输送.
  • 在手术后1天,3个月和6个月进行了连续血管学和血管内超声波评估.

主要成果:

  • 在15名患者的19个病变中成功植入了25个PLLA支架,血管学成功率为100%.
  • 在30天内没有发生支架血栓形成或重大心脏事件.
  • 在6个月后,每病变复原和目标病变再血管化率为10.5%,每患者率为6.7%. 没有观察到显著的支架反弹,在随访时成功扩张支架.

结论:

  • 初步结果表明,冠状动脉PLLA可生物降解支架在人类患者中是可行的,安全和有效的.
  • 伊加基-塔马伊PLLA支架显示出有希望的短期结果.
  • 需要对更大的患者队伍进行进一步的长期研究,以确认PLLA支架的持续疗效.