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Updated: May 11, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

聚氨酸调节p53乙化和因癌原Ras诱导的过早衰老

M Pearson1, R Carbone, C Sebastiani

  • 1European Institute of Oncology, Department of Experimental Oncology, Milan, Italy.

Nature
|July 26, 2000
PubMed
概括

促细胞白血病 (PML) 蛋白调节p53瘤抑制剂的作用.

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Negative Regulator Molecules01:23

Negative Regulator Molecules

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Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
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DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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Abnormal Proliferation

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