通过超声波检测细胞化微气泡进行炎症的非侵入性成像
J R Lindner1, P A Dayton, M P Coggins
1Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA. jlindner@virginia.edu
Circulation
|August 2, 2000
概括
微泡在炎症部位被免疫细胞细胞化,并且可以通过超声波检测到. 这种对比增强超声波技术对成像炎症组织有很大的前景.
科学领域:
- 生物医学工程 生物医学工程
- 诊断成像 诊断成像 诊断成像
- 免疫学 免疫学 免疫学
背景情况:
- 微泡以前被证明在炎症区域粘附于白细胞.
- 假设:微泡由中性粒细胞和单细胞细胞化,保持声学活跃以进行检测.
研究的目的:
- 为了研究细胞化微气泡是否在声学上保持活跃,并可在体内检测.
- 评估对比增强超声波在成像炎症方面的潜力.
主要方法:
- 试验室研究:通过显微镜观察的微泡化激活白细胞.
- 在体内研究:微泡注射后在小鼠体内显微镜和超声波成像.
- 评估了微气泡的附着,细胞,声学活动和超声波对比度增强.
主要成果:
- 微泡被中性粒细胞和单细胞细胞化,保持完整的时间长达30分钟.
- 与自由微气泡相比,在超声波下细胞化微气泡的破坏性降低.
- 在体内,炎症组织具有7倍多的细胞化微泡和5-6倍的超声波对比度增强.
结论:
- 细胞微气泡保持完整和响应声学.
- 与对比度增强的超声波可以在循环微气泡清除后,在体内检测细胞化微气泡.
- 这种技术有可能用于成像炎症部位.
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