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相关概念视频

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
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Regulation of Angiogenesis and Blood Supply01:24

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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相关实验视频

Updated: Apr 14, 2026

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles
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腺病毒介导的VEGF(121) 基因转移刺激了正常输出的骨肌中的血管生成,并在诱导缺血症后保持了组织输液.

L H Gowdak1, L Poliakova, X Wang

  • 1Gene Therapy Unit, Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

Circulation
|August 2, 2000
PubMed
概括

血管内皮生长因子 (VEGF) 的腺病毒介导基因转移刺激正常骨肌肉中的新血管生长. 这种新血管化改善了诱导性缺血症后的血液流动和组织 perfusion.

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科学领域:

  • 生物医学工程 生物医学工程
  • 分子生物学分子生物学
  • 血管生物学 血管生物学

背景情况:

  • 血管新生或新的血管形成对于治愈缺血组织至关重要.
  • 以前的研究没有证明血管新生诱导在健康的骨肌肉.
  • 这项研究调查了基因转移是否可以诱导非缺血性骨肌肉中的血管生成.

研究的目的:

  • 为了确定血管内皮生长因子 (VEGF) 的腺病毒介导的肌肉内基因转移是否可以刺激正常透的骨肌肉中的新血管化.
  • 评估这种诱导的新血管化是否可以缓解手术诱导缺血症后的血液动力学缺陷.

主要方法:

  • 子和老鼠接受了AdCMV.VEGF的肌肉内注射或对照载体.
  • 关节动脉的切除是为了诱导肢体缺血而进行的.
  • 评估了新血管化,组织输液,附带血管形成和肌肉生物能量.

主要成果:

  • AdCMV.VEGF(121) 注射显著增加了大动脉和毛细血管密度在老鼠的骨肌肉.
  • 与对照组相比,接受VEGF治疗的组显示,与对照组相比,缺血性四肢的血液流动和 perfusion 改善.
  • 在AdCMV.VEGF(121) 组中观察到增强的附带血管形成和改善的肌肉生物能量储备.

结论:

  • 肌肉内注射AdCMV.VEGF(121) 有效地刺激非缺血性骨肌中的血管生成.
  • 诱导的新血管化有助于在缺血开始后保持组织输液.