戒烟和男性与年龄相关的白内障风险
W G Christen1, R J Glynn, U A Ajani
1Division of Preventive Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
JAMA
|August 6, 2000
概括
戒烟显著降低了患年龄相关白内障的风险,主要是通过限制累积吸烟损害. 即使是长期吸烟的前吸烟者,与目前吸烟者相比,白内障的发病率也有所降低.
科学领域:
- 眼科医生 眼科 眼科
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 吸烟是与年龄相关的白内障的已知危险因素.
- 关于戒烟对白内障风险的影响现有的数据是不确定的.
研究的目的:
- 调查戒烟与与年龄相关的白内障发生率之间的联系.
- 量化了戒烟的个人对白内障的风险降低.
主要方法:
- 一项前性队列研究 (医生健康研究I),对20907名美国男性医生进行了平均13.6年的跟踪.
- 与年龄相关的白内障事件是由医疗记录确认的自我报告定义的,导致视力丧失或需要外科切除.
- 在基线评估了吸烟状态和戒烟以来的年份.
主要成果:
- 与目前的吸烟者相比,过去的吸烟者患白内障的风险较低 (相对风险 (RR) 从0.73到0.79).
- 从未吸烟的人有最低的风险 (RR=0.64).
- 前吸烟者的风险降低主要归因于较低的累积吸烟剂量,尽管一些分析表明剂量独立的好处.
结论:
- 戒烟显然可以降低与年龄有关的白内障的风险.
- 降低风险的主要机制是限制累积剂量相关的透镜损伤.
- 一些吸烟引起的透镜损伤在戒烟后可能是可逆的.
相关概念视频
Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
Menopause
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Statistical Methods for Analyzing Epidemiological Data
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
Stress Prevention and Stress Management Techniques IV
Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...


