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Updated: Jul 7, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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在表达核受体SXRR的小鼠中,人性化的异生生物反应

W Xie1, J L Barwick, M Downes

  • 1Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

Nature
|August 10, 2000
PubMed
概括

孕原X受体 (PXR) 和类固醇异生菌受体 (SXR) 被确定为关键的特定物种传感器. 这些受体通过肝脏的介导作用.

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Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes: