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定量超声波组织表征可以识别人体动脉动脉的高风险动脉样性变化

S Takiuchi¹, H Rakugi, K Honda

¹Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.

|August 16, 2000

概括

综合逆向散射 (IBS) 分析使用带超声波可以识别患有系统性动脉样硬化的高风险个体. 该方法为早期冠状动脉心脏病检测提供预后信息.

科学领域:

心血管超声波是什么意思
动脉样硬化成像动脉样硬化成像
生物医学工程生物医学工程

背景情况:

使用集成反射散射 (IBS) 分析对斑块组成进行了定量超声波组织表征.
以前的研究通常依赖于高频超声波进行显微镜成像.

研究的目的:

用7.5MHz传感器评估IBS分析的实用性,以鉴定人类大动脉和动脉中的动脉样性斑块.
评估IBS在识别系统性动脉样硬化和冠心病高风险个体的预后价值.

主要方法:

用声密度计进行B模式测量和IBS信号分析,对切除的人类大动脉进行测量 (n=58).
该方法应用于各种年龄和风险群体的人类带超声波,包括年轻人,低风险,高风险中年人,老年人和心肌梗塞患者.

主要成果:

动脉瘤组织显示IBS值低于纤维组织,尽管内膜介质厚度 (IMT) 类似.
与低风险受试者相比,状心脏梗塞的IBS值在老年人中显著高,在高风险中年人和心肌梗塞患者中较低.
动脉瘤斑块患病率 (由低IBS定义) 在低风险组为11%,中年高风险组为29%,心肌梗塞组为63%.

结论:

综合逆向散射 (IBS) 分析与B模式成像相结合,为带超声波提供预后信息.
这种方法可以识别患有系统性动脉样硬化的人,即使在早期阶段,他们也面临患冠状动脉疾病的高风险.

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