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核孤儿受体TR3的线粒体向诱导的细胞染色体c释放和亡.

H Li¹, S K Kolluri, J Gu

¹The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

Science (New York, N.Y.)

|August 19, 2000

概括

核转录因子TR3通过移动到线粒体,启动细胞亡. 这种线粒体转移,而不是DNA结合,是其细胞死亡诱导功能的关键.

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科学领域:

分子生物学分子生物学
细胞生物学细胞生物学
遗传学遗传学是一个

背景情况:

TR3是一种即时早期反应基因和转录因子.
TR3属于类固醇-甲状腺激素-回体受体超级家族.
TR3通过未知的机制调节细胞亡.

研究的目的:

阐明TR3调节亡的机制.
调查TR3转位在亡中的作用.

主要方法:

研究TR3.3的细胞局部化.
分析TR3转位对细胞亡的影响.
评估DNA结合和交换活化的必要性,以实现TR3的亲细胞突变功能.

主要成果:

作为对亡刺激的反应,TR3从核转移到线粒体.
线粒体转位TR3诱导细胞染色体c释放和亡.
TR3的益质效应取决于线粒体向,而不是DNA结合或交换活化.

结论:

TR3通过转移到线粒体来启动亡.
核转录因子可以转移到线粒体,触发亡.
线粒体向是TR3诱导细胞死亡的关键机制.