在人类瘤内皮表达的基因
B St Croix1, C Rago, V Velculescu
1Johns Hopkins Oncology Center, Howard Hughes Medical Institute, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Science (New York, N.Y.)
|August 19, 2000
概括
研究人员比较了正常和瘤血管细胞中的基因表达. 他们在瘤内皮上发现了与正常细胞不同的特定分子标记物,这些标记物可以为抗血管生成疗法提供信息.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 血管生物学 血管生物学
背景情况:
- 瘤血管生成对于癌症生长和转移至关重要.
- 了解正常和瘤血管之间的分子差异是针对性治疗的关键.
研究的目的:
- 为了确定正常和恶性结直肠组织之间的内皮细胞中的分子差异.
- 发现新的瘤内皮标记物,用于潜在的治疗点.
主要方法:
- 从正常和瘤结直肠组织中分离出的内皮细胞的基因表达概况.
- 差异表达分析以识别显著改变的转录.
主要成果:
- 分析了超过170个内皮主导的转录.
- 79个转录表现出差异性表达,其中46个在瘤内皮中特别升高.
- 在伤口愈合和黄体体形成期间,在正常血管中也发现了确定的瘤内皮标记物.
结论:
- 瘤和正常内皮表现出不同的分子谱.
- 新型瘤内皮标记物可能作为抗血管生成疗法的标.
- 这些发现凸显了开发针对血管生成依赖疾病的向治疗的潜力.
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