血大脑 natriuretic作为一个预后指标,在患有原发性肺高血压的患者
N Nagaya1, T Nishikimi, M Uematsu
1Division of Cardiology, Department of Medicine, National Cardiovascular Center, Osaka, Japan.
Circulation
|August 23, 2000
概括
高血大脑尿性 (BNP) 水平预测了原发性肺高血压 (PPH) 的死亡率. 在随访期间BNP的增加与PPH患者的死亡风险增加密切相关.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 生物标志物 生物标志物
背景情况:
- 血大脑尿性 (BNP) 水平与肺高血压中的右心室功能障碍相关.
- 初级肺高血压 (PPH) 是一个重大的临床挑战.
研究的目的:
- 在被诊断为PPH的患者中评估血BNP的预后值.
- 确定BNP水平是否可以预测PPH中的死亡率.
主要方法:
- 血BNP在诊断时测量了60名PPH患者,并在3个月的随访期间测量了53名患者.
- 多变量分析和卡普兰-梅尔生存曲线被用来评估预后意义.
- 49名患者接受了前环素治疗.
主要成果:
- 基线血BNP是PPH患者死亡率的独立预测因子.
- 具有较高基线BNP (>="150" pg/mL) 的患者的生存率明显较低.
- 在随访期间,幸存者的BNP水平下降,非幸存者的BNP水平增加,随访BNP (>= "180" pg/mL) 较高表明生存情况较差.
结论:
- 血BNP水平升高与PPH患者的死亡率增加密切相关.
- 随访期间血BNP的上升趋势进一步表明预后不佳,死亡风险增加.
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