叶酸是否会降低血类固醇蛋白,并改善透前脏衰竭患者的内皮功能?
J Thambyrajah1, M J Landray, F J McGlynn
1Division of Medical Sciences (Cardiology), University of Birmingham Birmingham, UK. J.Thambyrajah@bham.ac.uk
Circulation
|August 23, 2000
概括
高剂量的叶酸降低了慢性功能衰竭患者的高血糖血症,但没有改善内皮功能. 这表明叶酸可能不会减少尿血病中的血管疾病负担.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管医学 心血管医学
- 营养科学 营养科学
背景情况:
- 超homocysteinemia是一种独立的血管风险因素,与动脉样硬化和内皮功能障碍有关.
- 慢性功能衰竭 (CRF) 与高血糖蛋白血症和动脉样硬化有关.
- 叶酸对CRF患者血管事件的影响尚不清楚.
研究的目的:
- 为了研究叶酸对透析前慢性功能衰竭患者内皮功能的影响.
- 为了确定叶酸补充是否可以改善这种患者群体的血管健康标志物.
主要方法:
- 一项前性,双盲,安慰剂控制的研究,涉及100名前透析CRF患者.
- 患者每天接受 5 毫克叶酸或安慰剂,持续 12 周.
- 通过手臂动脉扩张,血清酸盐/酸盐水平和血勒布兰德因子度来评估内皮功能.
主要成果:
- 与安慰剂相比,叶酸补充剂显著增加了叶酸水平,并减少了超同类素蛋白血症.
- 在叶酸和安慰剂组之间没有观察到内皮依赖扩张,血清酸盐/酸盐或血勒布兰德因子的显著差异.
- 叶酸治疗降低了,但没有使高homocysteinemia水平正常化.
结论:
- 高剂量的叶酸有效地降低,但不会使预透析CRF患者的高同胞蛋白血症正常化.
- 叶酸补充剂在这个队列中没有改善内皮功能.
- 这些发现表明,叶酸治疗可能无法减轻与尿血相关的血管疾病负担.
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