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患有限制性心肌病的儿童的突然死亡和心血管崩
S M Rivenes1, D L Kearney, E O Smith
1Department of Pediatrics, (Cardiology), Texas Children's Hospital and Baylor College of Medicine, Houston 77030, USA. srivenes@bcm.tmc.edu
Circulation
|August 23, 2000
概括
儿童限制性心肌病 (RCM) 预后不佳. 患有RCM的儿童突然死亡的危险因素包括胸痛或心力衰竭的昏迷,这表明缺血是关键问题.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 心血管研究研究心血管研究
- 突发心脏病死亡病因 病因学
背景情况:
- 限制性心肌病 (RCM) 是一种罕见的儿科疾病,预后不佳.
- 突然心脏病死亡是受影响儿童的一个重大问题.
- 这项研究调查了儿科RCM患者的临床结果和死亡原因.
研究的目的:
- 评估RCM儿科患者的临床结果和死亡原因.
- 为了确定预测这一群体突然死亡的风险因素.
- 分析缺血在RCM相关死亡率中的作用.
主要方法:
- 在31年内对18名儿科RCM患者进行了回顾性审查.
- 突发死亡和没有突发死亡的患者之间的临床表现,病程和实验室数据的比较.
- 组织病理学检查,以寻找心肌缺血的证据.
主要成果:
- 患有突然死亡风险的患者通常是女孩,胸部疼痛或昏迷,没有心力衰竭.
- 霍尔特监测缺血的证据,虽然在统计学上对于突然死亡并不显著,但预测死亡数月内.
- 组织病理性缺血是常见的,急性缺血在经历突然死亡事件的人中更为普遍.
结论:
- 所有儿科RCM患者都面临与缺血相关的并发症和死亡的风险.
- 突然死亡的风险与明显的福祉有关,但缺血症的迹象 (胸痛,昏迷).
- 对于高风险儿科RCM患者,建议使用心电图,霍尔特监视器,β阻塞,ICD和心脏移植列表.
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