羊羔心肌代谢的周产期变化
B Bartelds1, H Knoester, G B Smid
1Division of Pediatric Cardiology, Department of Pediatrics, Beatrix Children's Hospital, Groningen, The Netherlands. b.bartelds@planet.nl
Circulation
|August 23, 2000
概括
心肌的氧气消耗从胎儿羔羊的葡萄糖转移到新生儿的长链脂肪酸 (LC-FA). 胎儿羔羊可以在供应时利用LC-FA来获得能量,在心肌基质利用方面表现出适应性.
科学领域:
- 心脏病学 心脏病学
- 新生儿生理学 新生儿生理学
- 代谢研究研究 代谢研究
背景情况:
- 乳酸是新生儿的心肌中重要的氧气消耗物.
- 成人心脏代谢的主要燃料来源,长链脂肪酸 (LC-FA),在胎儿和新生儿的心脏中受到质疑.
- 了解心肌基质利用对于新生儿心脏健康至关重要.
研究的目的:
- 为了研究葡萄糖和LC-FA在胎儿和新生儿羔羊心肌中的代谢命运.
- 为了确定葡萄糖和LC-FA对心肌氧消耗在围产期的贡献.
- 评估胎儿心脏利用LC-FA作为能量基质的能力.
主要方法:
- 使用稳定同位素标记物,[U-(13) C]葡萄糖和[1-(13) C]棕酸盐,在长期使用仪器的胎儿和新生儿羔羊中.
- 测量了心肌基质氧化率及其对整体氧气消耗的贡献.
- 向胎儿羔羊施用脂肪乳液,以增加LC-FA供应并评估代谢反应.
主要成果:
- 在胎儿羔羊中,葡萄糖是主要基质 (48%),LC-FA氧化率最小 (2%).
- 在新生羔羊中,LC-FA氧化显著增加 (83%),而葡萄糖氧化减少 (12%).
- 在脂肪输注期间,胎儿羔羊LC-FA氧化增加了15倍,对心肌氧耗氧有显著的贡献 (70%).
结论:
- 心肌基质利用率从胎儿的葡萄糖大幅转移到新生儿的LC-FA.
- 胎儿心肌具有利用LC-FA作为可用的实质性能量来源的能力.
- 这些发现阐明了新生儿心脏能量代谢的关键发育变化.
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