运动后缺血与冠状动脉疾病患者的神经Y的增加有关
L Gullestad1, B Jorgensen, T Bjuro
1Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway. lagulles@online.no
Circulation
|August 30, 2000
概括
神经Y (NPY) 水平与冠状动脉疾病患者的运动诱导心肌缺血相关. 较高的NPY水平与更大的ST段抑郁和更长的恢复时间有关,这表明NPY水平较高.
科学领域:
- 心血管生理学心血管生理学
- 神经内分泌学神经内分泌学
背景情况:
- 神经激素在运动期间和运动后影响血管度.
- 神经Y (NPY),与上腺素共释放,是一种强大的血管收缩剂.
研究的目的:
- 调查神经Y (NPY) 与冠状动脉疾病患者的运动诱导心肌缺血之间的关联.
主要方法:
- 对29名患有胸痛的男性患者进行了症状限制性运动测试.
- 用传统方法和HR调整的斜率/恢复循环分析了ST细分的变化.
- 血神经激素水平 (NPY,NE,上腺素,NT-proANP,大内分泌素) 被测量在运动前,运动期间和运动后.
主要成果:
- 运动诱导了显著的ST段抑郁,并增加了血NPY,上腺素 (NE) 和上腺素水平.
- NPY和NT-proANP在运动后4分钟达到峰值,而NE和上腺素在最大运动时达到峰值.
- 最大NPY增加与ST段抑郁,ST赤字和运动后ST抑郁的持续时间有显著的相关性.
结论:
- 血NPY水平与冠状动脉疾病患者的运动后ST段抑郁症的严重程度和持续时间相关.
- 在这种患者群体中,NPY可能在促进心肌缺血方面发挥作用.
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