氧化应激和阿司匹林不敏感的血栓素生物合成在严重的不稳定性心痛
F Cipollone1, G Ciabattoni, P Patrignani
1Department of Medicine and Aging, University of Chieti "G. D'Annunzio" School of Medicine, Chieti, Italy.
Circulation
|August 30, 2000
概括
不稳定的心痛会增加F(2) - 异质的产量,与抗阿司匹林的血小板素生物合成有关. 这表明抗氧化剂可以通过减少氧化应激来帮助管理不稳定的心痛.
科学领域:
- 心血管医学 心血管医学
- 生物化学 生物化学
- 氧化压力研究研究 氧化压力研究
背景情况:
- 不稳定性心痛的特点是脂质过氧化增加和抗氧化能力降低.
- 以前的研究表明,在不稳定的心痛中,在某些血小板激活发作期间,阿司匹林在抑制血小板糖生物合成方面无效.
- 这项研究研究了8-iso-prostaglandin F(2alpha) (8-iso-PGF(2alpha) 的作用,这是一种脂质过氧化标志物,在不稳定的心痛中,以及它对阿司匹林不敏感的血栓素产生潜在的贡献.
研究的目的:
- 为了确定体内8-iso-PGF的形成是否在不稳定的心痛中升高.
- 调查增强的8-iso-PGF和阿司匹林不敏感的血栓素生物合成之间的关联.
- 探索8-iso-PGF(2alpha) 水平,血栓糖的产生,和抗氧化剂的状态在不稳定的心痛患者之间的关系.
主要方法:
- 从患有不稳定性胸痛 (n=32),稳定性胸痛 (n=32),变异性胸痛 (n=4) 和健康对照组 (n=40) 的患者收集尿液样本.
- 通过免疫试验测量尿中的8-异构PGF{2α}和11-脱甲乙{2} (TXB{2})
- 与11-dehydro-TXB(2) 排泄和血维生素E度相关的8-iso-PGF(2alpha) 水平.
主要成果:
- 在不稳定的心痛患者中,与稳定的心痛患者和健康对照人群相比,尿液中的8-iso-PGF(2alpha) 排泄量显著更高.
- 在不稳定的胸痛患者中,在8-iso-PGF(2alpha) 和11-dehydro-TXB(2) 排泄之间观察到显著的正线性相关性.
- 升高的8 - 异位PGF ((2α) 水平与血维生素E水平相反相关,表明抗氧化防御减少.
结论:
- 这项研究确定了氧化应激增加和在不稳定性心痛中对阿司匹林不敏感的血栓糖生物合成之间的生化联系.
- 研究结果表明,高水平的8-iso-PGF ((2alpha) 在不稳定性胸痛的病理生理学中起作用.
- 这些结果为研究抗氧化剂在治疗不稳定性胸痛方面的有效性提供了科学依据.
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