在皮层限制的NMDAR1的干扰会损害在皮层的神经元模式
T Iwasato1, A Datwani, A M Wolf
1Laboratory for Behavioral Genetics, Brain Science Institute, RIKEN, Saitama, Japan.
Nature
|August 30, 2000
概括
皮质N-甲基-D-酸盐受体 (NMDARs) 对于感官地图的发展至关重要. 在激发性神经元中删除NMDAR1会破坏体感皮层中的桶形和thalamocortical模式.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 感官系统 感官系统
背景情况:
- 人体感官皮层包含感官输入的地形表示,如胡须和爪子.
- 神经活动,特别是通过N-甲基-D-酸盐受体 (NMDARs),涉及到感官地图的发展,但其确切的作用仍在争论中.
研究的目的:
- 调查皮质NMDARs对于体感皮质地图和结构的发展的必要性.
主要方法:
- 产生的转基因小鼠具有NMDAR1基因删除,特别是在刺激性皮质神经元.
- 使用这些小鼠检查了大脑干,大脑丘脑和体感皮层中感觉路径的发展.
主要成果:
- 大脑干和丘脑中的感觉地图正常发展.
- 在皮质中,大胡须的thalamocortical afferents显示出一些图案和可塑性,但不如对照组那么明显.
- 鼻毛和手指的图案基本上没有.
- 细胞聚合物 (桶) 和它们的边界未能形成,即使在 afferents 聚集的地方.
结论:
- 皮层NMDAR对于IV层细胞正确聚合到桶中至关重要.
- 在体感皮层中,NMDARs是必要的,以使 thalamocortical 模式的完整发展.
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