与年龄相关的智力下降与健康八十岁人的脑白质过强度之间的关系:一项纵向研究
E Garde1, E L Mortensen, K Krabbe
1Danish Research Centre of Magnetic Resonance, Copenhagen University Hospital, Hvidovre. elleng@magnet.drcmr.dk
Lancet (London, England)
|September 1, 2000
概括
在老年人中常见的白质过强度与认知能力下降有关. 这项研究发现,这些MRI发现与几十年来智力功能下降有关,特别是在生命的最后十年.
科学领域:
- 神经学 神经学
- 老年病的医生 老年病的医生
- 神经成像是一种神经成像.
背景情况:
- 白质超强度 (WMH) 经常通过MRI观察到老年人,经常有或没有痴呆症.
- 之前关于WMH严重程度与认知障碍之间的关系的研究已经产生了不一致的结果.
- 进行了一项纵向研究,以调查与年龄相关的认知衰退及其与八十岁人群中WMH的关联.
研究的目的:
- 检查白物质强度 (WMH) 与健康老年人的认知衰退之间的纵向关系.
- 评估周周和深层WMH与从50岁到80岁的智力功能下降的关联.
- 确定WMH对80岁前十年认知变化的影响.
主要方法:
- 一组68名健康的,没有痴呆症的个人,最初是1914年出生的更大群体的一部分,在50岁,60岁,70岁和80岁时使用韦克斯勒成人智力表 (WAIS) 进行了反复的认知测试.
- 大脑磁共振成像 (MRI) 对80-82岁的参与者进行了测试.
- 在MRI扫描上分别量化了周腹腔和深白质超强度.
主要成果:
- 周周结膜或深层白质过强度都与80岁的整体智商得分无关.
- 这两种类型的白质超强度都与从50岁到80岁的表现智商下降有显著的相关性.
- 白质过强度和认知衰退之间的关联在70-80岁的年龄十年中最为明显.
结论:
- 周周结膜和深深的白质过强度都与健康的八十岁人的智力下降有关.
- 然而,这些MRI发现仅仅只占与年龄相关的认知衰退的个体变异性的一小部分.
- 对老年人白质过强度的诊断解释需要仔细考虑,因为它们与认知衰老的复杂关系.
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