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相关概念视频

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
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Published on: July 22, 2020

瘤血管发生. 确定了基因表达模式的基因表达模式.

J Marx

    Science (New York, N.Y.)
    |September 2, 2000
    PubMed
    概括
    此摘要是机器生成的。

    研究人员绘制了瘤血管基因图,揭示了与正常组织的明显差异. 这一发现可能会导致针对瘤血管的新药用于癌症治疗.

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    科学领域:

    • 在瘤学瘤学.
    • 血管生物学 血管生物学
    • 基因组学就是基因组学.

    背景情况:

    • 瘤生长依赖于血管生成,即新血管的形成.
    • 了解瘤血管结构中的遗传差异对于开发向疗法至关重要.

    研究的目的:

    • 为了比较人类结肠癌患者血管中的基因表达与正常结肠组织的基因表达.
    • 为了识别瘤血管结构的独特分子特征.
    • 探索抗癌药物开发的潜在治疗点.

    主要方法:

    • 大规模的基因表达分析.
    • 在与瘤相关的血管和正常的结肠血管中对基因产品的比较分析.
    • 鉴定差异表达的基因及其蛋白质产物.

    主要成果:

    • 在人类结肠癌患者的血管和正常结肠组织之间确定了不同的基因表达模式.
    • 特定的基因在瘤血管系统中过度表达.
    • 这些发现提供了瘤血管发育的详细分子地图.

    结论:

    • 在基因表达中发现的差异为新型抗癌药物提供了潜在的点.
    • 向瘤血管中过度表达的蛋白质可以抑制血管生成和瘤生长.
    • 这项研究促进了对瘤血管化和治疗策略的理解.